The mission of neuroscience research at VIB is to advance the understanding of the brain and enhance the ability to effectively treat complex neurodegenerative diseases affecting the central and peripheral nervous systems. VIB scientists tackle biological questions related to synapses, neuronal networks, and connectivity, with a primary focus on the disruption of these functions in disease-related processes. Our research encompasses the neurobiology and neurogenetics of major neurodegenerative disorders, such as Alzheimer's disease, frontotemporal dementia, Parkinson's disease, and ALS, as well as various neuronal disorders, including epilepsy, dystonia, ataxia, intellectual disabilities, peripheral neuropathy, and spastic paraplegia. To accomplish this mission, VIB researchers use cutting-edge technologies that bridge circuit activity and brain function, harness modern human molecular genetics and genomic approaches, and explore cellular, developmental, and systems biology.